Research Areas Functional Nanomedicine

Research Interests GENE DELIVERY FUNCTIONAL NANOMEDICINES
The Functional Nanomedicine Lab is developing nano-delivery system that can effectively deliver gene-based therapeutic drug such as siRNA and mRNA. In general, in order to overcome the limitations of intracellular delivery of nanomedicines such as low efficient endocytosis mechanism, our lab has developed a technology called nano-drill technology that can deliver nanomedicine directly through the cell membrane. The technology demonstrates significantly higher delivery efficiency than general nanomedicines. Using the developed technology, we are developing mRNA vaccines and siRNA-based functional nanomedicines for the treatment of cancer and immune-related diseases.

NATURAL SUBSTANCES BASED FUNCTIONAL NANOMEDICINE FOR CANCER IMMUNOTHERAPY AND IMMUNE-RELATED DISEASES.
The Functional Nanomedicine Lab is developing nanostructures using peptide and protein based natural materials. The developed nanostructures maintain the therapeutic functions of the natural materials; while significantly reducing toxicity and improving stability. The developed natural materials-based nanomedicines are being optimized to be developed as therapeutic agents for cancer and immune-related diseases such as Rheumatoid Arthritis.

Selected Publications Yongho Jang, Haemin Kim, Semi Yoon, Hohyeon Lee, Jangsun Hwang, Jaehun Jung, Jin Ho Chang, Jonghoon Choi, Hyuncheol Kim, “Exosome-based photoacoustic imaging guided photodynamic and immunotherapy for the treatment of pancreatic cancer”, J Control Release 330 (2021) 293-304

Hyounkoo Han, Doyeon Kim, Yongho Jang, Minkyu Seo, Kwangmeyung Kim, Jong Bum Lee, Hyuncheol Kim, “Focused ultrasound-triggered chemo-gene therapy with multifunctional nanocomplex for enhancing therapeutic efficacy”, J Control Release 322 (2020) 346-356

Doyeon Kim, Jae Hwan Lee, Hyungwon Moon, Minkyu Seo, Hyounkoo Han, Hongkeun Yoo, Howon Seo, Jingu Lee, Sujung Hong, Pilhan Kim, Hak Jong Lee, Jin Wook Chung, Hyuncheol Kim, “Development of evaluation of an ultrasound-triggered microbubble combined transarterial chemoembolization (TACE) formulation on rabbit VX2 liver cancer model”, Theranostics 11 (2021) 79-92

Hohyeon Lee, Jieun Han, Heejun Shin, Hyounkoo Han, Kun Na, Hyuncheol Kim, “Combination of chemotherapy and photodynamic therapy for cancer treatment with sonoporation effects”, J Control Release 283 (2018) 190-199

Doyeon Kim, Suhyun Park, Hongkeun Yoo, Suhyeon Park, Jeewon Kim, Kyuhee Yum, Kwangmeyung Kim, Hyuncheol Kim, “Overcoming anticancer resistance by photodynamic therapy-related efflux pump deactivation and ultrasound-mediated improved drug delivery efficiency, Nano Converg 7 (2022) 30

Hohyeon Lee, Yongho Jang, Suhyun Park, Hyejin Jang, Eun-Joo Park, Hyun Jung Kim, Hyuncheol Kim, “ Development and evaluation of a CEACAM6-targeting theranostic nanomedicine for photoacoustic-based diagnosis and chemotherapy of metastatic cancer”, Theranostics 8 (2018) 4247-4261

Professional Experience 박사후연구원 (미국립보건원, 2004-2007)
연구조교수 (듀크의과대학, 2007-2008)