Research Areas Nano bioelectronics

Research Interests Assembloid (Brain organoid, Retinal organoid)
Different living tissues in the human body interact and work together to operate. An assembloid made of the direct connection of various live tissues was created to mimic this in vitro. Our group generated a variety of organoids, including cerebral, midbrain, cerebellar, thalamic, and retinal organoids, that imitate distinct regions of the tissues. We then put these organoids together to create new forms of assembloid. Additionally, the connection effectiveness and signal transduction capabilities of connected organoids were enhanced by the introduction of nanomaterials. Our group is researching the development of biohybrid robots and assembloid-on-a-chip that can be utilized for drug screening.

Nano-biohybrid Robot
Biohybrid robots by integrating live biological elements hold promise to develop the next generation of stimuli-responsive, energy-efficient, automated robots capable of navigating complex surroundings and performing a number of otherwise formidable tasks. Instead of humans and other living things, biohybrid robots can be used in various fields such as drug screening and toxicity assessment. Recently, we have developed a biohybrid robot composed of nanoparticle-embedded muscle bundles to augment the actuation and monitor positive and negative inotropic effects.

Exosome based nanobiosensor to detect cancer
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. exosomes are mediators of near and long-distance intercellular communication in health and disease and affect various aspects of cell biology. Recently, we have developed an innovative exosomal miRNA detection method to monitor stem cell neurogenesis in nondestructive, selective, and sensitive manner using multifunctional magneto-plasmonic nanorods.

Selected Publications Jinho Yoon, Hyun-Woong Kim, Minkyu Shin, Joungpyo Lim, Ji-Young Lee, Sang-Nam Lee, Jeong-Woo Choi, “3D Neural Network Composed of Neuroshperoid and Bionanohybrid on Microelectrode Array to Realize the Spatial Input Signal Recognition in Neurospherid”, Small Methods 6 (2022) 2200127.

Jin-Ha Choi, Joungpyo Lim, Minkyu Shin, Se-Hwan Baek, Jeong-Woo Choi, “CRISPR-Cas12a-Based Nucleic Acid Amplification-Free DNA Biosensor via Au Nanoparicle-Assisted Metal-Enhanced Fluorescence and Colorimetric Analysis”, Nano Letters 21 (2021) 693-699.

Jin-Ha Choi, Minkyu Shin, Letao Yang, Brian Conley, Jinho Yoon, Sang-Nam Lee, Ki-Bum Lee, Jeong-Woo Choi, "Clustered Regularly Interspaced Short Palindromic Repeats-Mediated Amplification-Free Detection of Viral DNAs Using Surface-Enhanced Raman Spectroscopy-Active Nanoarray", ACS Nano 15 (2021) 1375-13485.

Taek Lee, Mohsen Mohammadniaei, Hui Zhang, Jinho Yoon, Hye Kyu Choi, Sijin Guo, Peixuan Guo, Jeong-Woo Choi, "Single Functionalized pRNA/Gold Nanoparticle for Ultra-Sensitive MicroRNA Detection Using Electrochemical Surface-Enhanced Raman Spectroscopy", Advanced Science 7 (2020) 19024.

Sung-Jin Park, Mattia Gazzola, Kyung Soo Park, Shirley Park, Valentina Di Santo, Erin L. Blevins, Johan U. Lind, Patrick H. Campbell, Stephanie Dauth, Andrew K. Capulli, Francesco S. Pasqualini, Seungkuk Ahn, Alexander Cho Hongyan Yuan, Ben M. Maoz, Ragu Vijaykumar, Jeong-Woo Choi, Karl Deisseroth, George V. Lauder, L. Mahadevan,Kevin Kit Parker, "Phototactic guidance of a tissue-engineered soft-robotic ray", Science 353 (2016) 158-162.

Professional Experience 서강대학교 화공생명공학과 교수 (1990-현재)
서강대학교 공과대학 학장 (2021-2022)
서강대학교 정보통신대학원 원장 (2021-2022)
한국바이오칩 학회 회장 (2009)
한국생물공학회 회장 (2017)
서강-하버드 질병바이오물리 연구센터 센터장 (2013-2020)
국가과학기술위원회 심의회의 생명의료전문위원회 위원 (2019-2020)